論文雑誌「Journal of Medicinal Chemistry」のカバーピクチャーを制作しました［国立医薬品食品衛生研究所］

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin
D Synthase via In Silico Design
Hidetomo Yokoo, Norihito Shibata*, Akinori Endo, Takahito Ito, Yuta Yanase, Yuki Murakami,
Kiyonaga Fujii, Kengo Hamamura, Yasushi Saeki, Mikihiko Naito*, Kosuke Aritake*,
and Yosuke Demizu*

The cover shows a graphical illustration of a novel PROTAC molecule, PROTAC(H-PGDS)-6, that binds to hematopoietic prostaglandin D synthase (H-PGDS) with potent activity in the degradation of H-PGDS protein via the ubiquitin–proteasome system and in the suppression of prostaglandin D2 production

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