論文雑誌「Chemical Science」のカバーピクチャーを制作しました[東京農工大学]

弊社で制作しました東京農工大学 岡田洋平先生のカバーアートが
イギリスの王立化学会発行の学術雑誌 Chemical Science
2021年10月号 Front Coverに選ばれました。

カバーピクチャー 科学イラスト 論文表紙絵 アートアクション
Client
東京農工大学
大学院農学研究院応用生命化学部門 
岡田洋平先生
Journal
Chemical Science
21 October 2021,   Issue 39 Link
Biphasic electrochemical peptide synthesis
Shingo Nagahara, Yohei Okada, Yoshikazu Kitano and Kazuhiro Chiba

The large amount of waste derived from coupling reagents is a serious drawback of peptide synthesis from a green chemistry viewpoint. To overcome this issue, we report an electrochemical peptide synthesis in a biphasic system. Anodic oxidation of triphenylphosphine (Ph3P) generates a phosphine radical cation, which serves as the coupling reagent to activate carboxylic acids, and produces triphenylphosphine oxide (Ph3P=O) as a stoichiometric byproduct. In combination with a soluble tag-assisted liquid-phase peptide synthesis, the selective recovery of desired peptides and Ph3P=O was achieved. Given that methods to reduce Ph3P=O to Ph3P have been reported, Ph3P=O could be a recyclable byproduct unlike byproducts from typical coupling reagents. Moreover, a commercial peptide active pharmaceutical ingredient (API), leuprorelin, was successfully synthesized without the use of traditional coupling reagents.

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