論文雑誌「Chemical Science」のカバーアートを制作しました[中央大学]

弊社で制作しました中央大学 不破春彦先生のカバーアートが
イギリスの王立化学会発行の学術雑誌 Chemical Science
2021年1月号に選ばれました。

カバーピクチャー 科学イラスト 論文表紙絵 アートアクション 中央大学 不破先生
Client
中央大学
理工学部応用化学科  天然物有機化学研究室
不破 春彦 先生
Journal
Chemical Science
21 January 2021, Issue 3,  Page 817 to 1178 Link
Total synthesis and complete configurational assignment of amphirionin-2
Shota Kato, Daichi Mizukami, Tomoya Sugai, Masashi Tsuda and Haruhiko Fuwa

Abstract

Amphirionin-2 is a linear polyketide metabolite that exhibits potent and selective cytotoxic activity against certain human cancer cell lines. We disclose herein the first total synthesis of amphirionin-2 and determination of its absolute configuration. Our synthesis featured an extensive use of cobalt-catalyzed Mukaiyama-type cyclization of γ-hydroxy olefins for stereoselective formation of all the tetrahydrofuran rings found in the natural product, and a late-stage Stille-type coupling for convergent assembly of the entire carbon backbone. Four candidate diastereomers of amphirionin-2 were synthesized in a unified, convergent manner, and their spectroscopic/chromatographic properties were compared with those of the authentic material. The present study culminated in the reassignment of the C5/C7 relative configuration, assignment of the C12/C18 relative configuration, and determination of the absolute configuration of amphirionin-2.

The article was first published on 20 Nov 2020
Chem. Sci., 2021,12, 872-879
Link
  • 中央大学
  • Chemical Science
  • RSC
  • Cover Art
  • カバーピクチャー
  • 学術雑誌・ジャーナル
  • イラスト
  • 論文
  • 表紙絵
  • 制作実績